General, I give Youzhny an excellent chance to beat Djokovic indoors or on faster courts, like Rotterdam or Marseilles.
If Arthur Ashe plays faster tonight then I've seen it so far, then Youzhny might have a chance in 3 or 4, but if not, then probably Djokovic in 3 or 4.
This is a slam, best of 5, and I'm not sure Youzhny has what it takes mentally to beat Djokovic over best of 5, as long as Djokovic can defend like he does. You have to be able to hit winners against Djokovic or force him into making errors to shake his confidence, and if the court is high bouncing or slow enough, than Djokovic gets to a lot of balls that would be winners on lower bouncing faster surfaces and frustrates many opponents, like Nadal with his defense.
Still, anything can happen. I've seen stranger things... like Federer beating himself like he did vs. Robredo the other night. That was bizarre. He was like Jekyll and Hyde. He played fairly well in many games to get to break point, then played awfully when it counted. He handed that match to Robredo. He played quite well in the 3 matches previously. So it was very strange for me, almost shocking, general.
If I didn't know better, I'd say Uncle Toni was sticking a dagger into a Roger Federer voodoo doll on every break point.

Respectfully,
masterclass