If you count Murray as the contender then from qtr final on, he will have the toughest draw as he will have to play Tsonga/Federer, Nadal and then Nole.
If things go accordingly then Nadal will play Raonic/Dimitrov/Paire, followed by Murray/Federer/Tsonga, and then Nole.
Nole will have to go through Wawrinka/Robredo, Ferrer/Berdych, and the most likely scenario is Nadal.
So you pick. Which one do you think is the toughest and easiest. I personally feel they all have tricky opponents and some of the opponents probably won't even make it, but perhaps Nole is the person who's going to handle most of his opponents the best. He is only vulnerable to Nadal and Murray. He has lost last 4 of the 5 Slams to both Nadal and Murray if I am to point.
This also tells me one thing. If Noel makes the final, he will be very tough to beat. I am sure it took him long to forget about those losses and this AO is his holy grail, so rest assured, he will be on it as if there's no tomorrow.